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| Registros recuperados: 2.284 | |
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| Xuebo Hu; Sungkwon Kang; Xiaoyue Chen; Charles B. Shoemaker; Moonsoo M. Jin. |
| High throughput methods to measure protein-protein interactions will facilitate uncovering pairs of unknown interactions as well as designing new interactions. We have developed a platform to detect protein interactions on the surface of yeast, where one protein (bait) is covalently anchored to the cell wall and the other (prey) is expressed in secretory form. The prey is released either outside of the cells or remains on the cell surface by its binding to the bait. The strength of their interaction is measured by antibody binding to the epitope tag fused to the prey or direct readout of split fluorescence protein complementation. Our novel 'yeast surface 2-hybrid' system was found to differentiate 6-log difference in binding affinities... |
| Tipo: Manuscript |
Palabras clave: Biotechnology. |
| Año: 2008 |
URL: http://precedings.nature.com/documents/2067/version/1 |
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| Monica Gori; Michela Del Viva; Giulio Sandini; David C. Burr. |
| Several studies have shown that adults integrate visual and haptic information (and information from other modalities) in a statistically optimal fashion, weighting each sense according to its reliability. To date no studies have investigated when this capacity for cross-modal integration develops. Here we show that prior to eight years of age, integration of visual and haptic spatial information is far from optimal, with either vision or touch dominating totally, even in conditions where the dominant sense is far less precise than the other (assessed by discrimination thresholds). For size discrimination, haptic information dominates in determining both perceived size and discrimination thresholds, while for orientation discrimination vision dominates. By... |
| Tipo: Manuscript |
Palabras clave: Neuroscience. |
| Año: 2008 |
URL: http://precedings.nature.com/documents/1521/version/1 |
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| Registros recuperados: 2.284 | |
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